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It replaces the standard Windows . driver with a set of drivers dedicated for your machine. In addition to providing the most efficient graphically based interface for common hardware functions, WinLINE provides a wide range of advanced features that will transform your machine into a valuable tool. Features The following table summarizes the features of the WinLINE platform: References External links Official Website Category:Software companies of the United StatesNeuroprotective effects of modafinil and tolbutamide against rotenone toxicity in cultured PC12 cells and C57BL/6J mice. Modafinil (MTF) and tolbutamide (TOL) have been shown to be effective in the treatment of major depression. However, whether these drugs have neuroprotective effect is not known. This study examined the neuroprotective effects of MTF and TOL on rotenone-induced neurotoxicity in vitro and in vivo. PC12 cells were treated with MTF (10 µM) or TOL (5 µM) for 6 h and then co-incubated with rotenone (2 µM) for 24 h. The levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxytryptamine (5-HT) in the cell medium were measured using enzyme-linked immunosorbent assays. In addition, the expression levels of the Nrf2 and superoxide dismutase-1 (SOD-1) proteins and the neuronal cell death in the cell medium were analyzed by Western blotting and the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay, respectively. To determine the neuroprotective effect of MTF and TOL in vivo, C57BL/6J mice were given 1 mg/kg of rotenone daily for 21 days. Then, MTF (5 mg/kg) or TOL (100 mg/kg) was administered to the mice for 7 days, and changes in memory function were assessed using the Y-maze test. The results showed that rotenone decreased the levels of dopamine and DOPAC, and increased the levels of HVA and 5-HT in the cell medium of PC12 cells. MTF or TOL treatment significantly increased the levels of dopamine, DOPAC,

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